HER2 Support Group Forums - View Single Post - beginnning of the end of her2+ breast cancer? Divide and conquer!

Lani · 09-22-2012, 10:28 PM

aspirin is a cox1 and cox 2 inhibitor--but in order to get antiinflammatory blood levels you need to take several every 4 hours or so--as are ibuprofen, naproxen, sulindac and several others. Of the NSAIDs naproxen is felt to be the safest with respect to cardiovascular side effects--all can cause stomach bleeding and rarely kidney problems as well.

Celebrex is ONLY a cox 2 inhibitor. It is unclear what the anticancer dosage would be and how often it must be taken vs the antiinflammatory dosage and frequency.

It is just lovely that there are already approved drugs in these categories with well understood side effects/safety profiles.

09-22-2012, 10:28 PM	#3
Lani Senior Member Join Date: Mar 2006 Posts: 4,780	Re: beginnning of the end of her2+ breast cancer? Divide and conquer! aspirin is a cox1 and cox 2 inhibitor--but in order to get antiinflammatory blood levels you need to take several every 4 hours or so--as are ibuprofen, naproxen, sulindac and several others. Of the NSAIDs naproxen is felt to be the safest with respect to cardiovascular side effects--all can cause stomach bleeding and rarely kidney problems as well. Celebrex is ONLY a cox 2 inhibitor. It is unclear what the anticancer dosage would be and how often it must be taken vs the antiinflammatory dosage and frequency. It is just lovely that there are already approved drugs in these categories with well understood side effects/safety profiles.