[Lani]

I have posted before that in mice there is an inherited her2+ breast cancer that is related to Fox P3, an important marker on immune cells called Tregulatory cells. The gene is located on the X-chromosome.

It is felt this might happen in people, but would probably be very rare.

Noone knows how rare, as most families with breast cancer have not had all members her2 tested, as the mother's or grandmother's breast cancer occurred long before her2 testing was widespread. I have started several threads about this and asked her2support members to list any family members they know had breast cancer and whether it was tested for her2==in most cases it was not.

I think this would be better used for those who have already had her2+ dcis or her2+ breast cancer. Sometimes the new lesion ends up being her2- second bcs or "dcis"es or recurrences that have become her2- under the influence of the preceding treatment , but it would seem that this new combination vaccine would be most helpful trying prevent those recurrences/dcis'es, or new invasive tumors that are again her2+ (probably the majority)