HER2 Support Group Forums - View Single Post - TDM-1. How quickly did it show it was working

Vicky · 07-21-2012, 08:02 PM

Hi Nancy,

I've actually done both tdm1 and eribulin, or halaven. After three doses of tdm1 all of my liver lesions disappeared and both my breast tumor, mets in spine and lymph nodes all shrunk. I remained stable after that for almost a year. When I progressed in my lungs I started halaven and herceptin and in 3 treatments again the lung mets were disappearing. I finished 5 treatments before my counts kept dropping and after 15 months of nonstop treatment I am on a short chemo break.

I was not feeling ill before I started tdm1 but I did have some discomfort in my back. As for side effects I had 2-3 days of nausea and some fatigue, but it was manageable.

I wish you healing and wellness as you navigate this next chapter!

07-21-2012, 08:02 PM	#4
Vicky Senior Member Join Date: May 2011 Posts: 137	Re: TDM-1. How quickly did it show it was working Hi Nancy, I've actually done both tdm1 and eribulin, or halaven. After three doses of tdm1 all of my liver lesions disappeared and both my breast tumor, mets in spine and lymph nodes all shrunk. I remained stable after that for almost a year. When I progressed in my lungs I started halaven and herceptin and in 3 treatments again the lung mets were disappearing. I finished 5 treatments before my counts kept dropping and after 15 months of nonstop treatment I am on a short chemo break. I was not feeling ill before I started tdm1 but I did have some discomfort in my back. As for side effects I had 2-3 days of nausea and some fatigue, but it was manageable. I wish you healing and wellness as you navigate this next chapter! __________________ 3-16-11 dx IDC 4.4 cm tumor, right breast,HER-2 neu 3+++, Stage III 3-25-11 PET scan shows 3 mets to liver and 1 to spine, Stage IV 4-12-11 start clinical trial of TDM1 infusion 1x every 3 weeks. 6-14-11 CT scan after 3 cycles shows NO liver spots, reduced spinal met from 18mm to 13mm and right breast mass from 4.4 to 4.2 cm. 8-12-11 Mastectomy rt. breast. 10-11 scans reflect stable cancer 12-11 MRI reveals area of concern in brain, CT scan reveals 3mm spot on lung. Watch and wait and rescan in a few weeks. Round 13 TDM1 complete. 2-21-12 Scans reveal progression in lungs with 4 new small mets. Officially off tdm1. Start halaven and radiation for single brain met, 1 spot in spine. 3-13 stereotactic radiosurgery for single brain met. 5-31-12 Halaven stopped due to low blood counts. Start tamoxifen and cont. Herceptin 1x3 weeks. 7-11-12- brain mri shows shrinking brain met and no new lesions. Cont. Herceptin and Tamoxifen 10-2-12 Stable tumor markers. Continue Herceptin and Tamoxifen 4-9-13 progression in lymph node under arm and new lung spots. Stop Tamoxifen. Add Xeloda to Herceptin. 6-10-13 Stereotactic radiosurgery to two new brain mets. Stop Xeloda due to lung mets progression. begin Tykerb 7-2-13. 10-29-13 Begin radiation to my lungs and one lymph node under my arm. Stop Tykerb until completion and then recommence. 1-31-14 Progression in lungs. Oophorectomy performed. 2-18-14 Begin Arimidex and continue Herceptin 7-7-15 progression with spots on colon, in pelvic region, and in lungs. Begin Taxotere, Perjeta and Herceptin. 11-15 Switch to weekly Taxol, and continue with Perjeta and Herceptin. 12-23-16 PET scan shows Complete Response with no new spots. Continue on with TPH indefinitely. 3-16-16 Still no evidence of disease, break from Taxol. Continue on with Perjeta and Herceptin.