[Kmswilson]

I just thought I'd weigh in. In January, I had a few blurry vision issues, and my doc sent me for a brain MRI, not really expecting it to show anything. It came back that I had nine very small lesions, and I had 13 WBR treatments and then started Tykerb and Xeloda. It was terrible. I did not tolerate Xeloda well at all. I was sick as a dog. A lot of vomiting, a ton of nausea, could not eat. A lot of diarrhea that I had troubles controlling with lomotil and immodium, diet changes, etc. In about three months of all of this, I lost about 32 lbs and had to get fluids multiple times a week for dehydration. Scans showed that the Xeloda had mixed results anyway, so my onc took me off the of the Xeloda and kept me on Tykerb and Herceptin. I was still very sick on the Tykerb, and after trying everything they could, they put me on 4mg of dexamethasone every 8 hours to help with the appetite and nausea. It did the trick. And my last brain MRI showed only one lesion left out of nine, and it's only 2 mm and shrinking. I would say definitely request a brain MRI, but the Xeloda and Tykerb combo was extremely nasty for me, worse than any of the chemo combos I've been on, and it made me really sick and sometimes dizzy. I went down in the athroom trying to dry off a couole of times, thankfully i was bent over slready and could kind of catch mysself! I really hope things have gotten much better for you guys by now!