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Old 05-10-2012, 02:40 PM   #8
rhondalea
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Join Date: Jun 2011
Location: Somerset, NJ
Posts: 487
Re: Guinea Pig - Metformin Trial

Hey Denise,

No immodium.

I spent most of my day in Mount Holly--going over the documents, giving information, getting information, being examined. And, as I mentioned earlier, tomorrow I have labs and an x-ray.

But no immodium.

I saw your post before I went racing out this morning, so when the diarrhea issue was raised, I asked. They have a protocol for addressing the side effects, but for the proper data gathering, they hope I will endure a certain amount of discomfort in order to see what works and what does not (this is mostly about dose adjustment).

It's okay. I'll live. The rest of this is TMI (you've been warned), but I'll tell you anyway: I have what appears to be some kind of hereditary "slow bowel transit" going on (in addition to the whole hypothyroid thing). This late in the game, I have more control of it than it has of me, but a few months of unplugged pipes would actually be kinda nice. (I'm the only person I know who enjoyed her colonoscopy prep. Well, sort of.)

The good news is that I solemnly promise not to tell you when I'm posting from the bathroom.
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2/6/09 Core needle biopsy: negative; Mammos through 2010: no change
3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much
4/14/11 Core needle biopsy: negative for cancer
5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5
6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3
7/14/11 CT/Bone scans NED; MUGA 66%
7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11
9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64%
9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012
12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy!
2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17
5/16/12 Start five-years Metformin trial
6/19/12 MUGA 61%
8/21/12 Brain MRI NED (head still hurts, brain still fogged)
9/4/12 Herceptin done!
9/6/12 Port out!
7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013
5/2014 Add Namenda 7mg
9/2014 Stop Aricept and Namenda; Neuropsychological evaluation
10/24/14 Start cognitive rehabilitation therapy
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