[Lani]

You are missing the concepts of both synergism and of blocking multiple pathways of escape

A +B can work even if A or B alone do not


If you have a puppy who wants to escape the house and play in the backyard, locking the front door may not be enough. As it grows up and learns more it may escape out the back door. As it grows up even more and can jump it, it may jump on top of the dresser and hop out the open window.

Just because other chemos don't work, it doesn't mean that there aren't chemos to close other open windows. and reopening the front door but closing more windows definitely is not the best way.

her2 is the front door and herceptin has proven better than lapatinib in closing that front door so side windows of the front door don't open up soon. Closing the front door and its side windows is especially good. ie tykerb+herceptin

Hope this helps