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MJsHusband · 05-03-2012, 11:56 AM

I'm hoping we are not at the point where we need to request compassionate use. Do you all think we are at that point where we are quickly running out of options? Should I lower my expectations for Tykerb/Xeloda? MJ started her second round of Xeloda this week in addition to the 5 daily Tykerb pills.

I am hoping TDM-1 is a game changer, like Herceptin was thought to be. It seems Herceptin doesn't work for everyone and for those who do respond, it stops working on it's own after a number of months/years. I am reading about the success some are having using Herceptin in combination with other chemo drugs and that's a good thing. I guess I'm a bit let down after Herceptin allowed the endometrial tumors to grow so quickly. To me, it's not the "game changer" that I first read about when MJ was diagnosed. I still remember the hope I had when I first read "Her2 had a poor prognosis before Herceptin". Now I can't help but think, what if it doesn't work in combination with other drugs for MJ? I saw a study that even when Herceptin is added to Tykerb, overall survival is only extended 4 months. Is it too much to want more than that?

Sorry for the "blah" posting today. It's just how I'm feeling.

~Greg

05-03-2012, 11:56 AM	#33
MJsHusband Senior Member Join Date: Apr 2012 Posts: 87	Re: Treatment Question I'm hoping we are not at the point where we need to request compassionate use. Do you all think we are at that point where we are quickly running out of options? Should I lower my expectations for Tykerb/Xeloda? MJ started her second round of Xeloda this week in addition to the 5 daily Tykerb pills. I am hoping TDM-1 is a game changer, like Herceptin was thought to be. It seems Herceptin doesn't work for everyone and for those who do respond, it stops working on it's own after a number of months/years. I am reading about the success some are having using Herceptin in combination with other chemo drugs and that's a good thing. I guess I'm a bit let down after Herceptin allowed the endometrial tumors to grow so quickly. To me, it's not the "game changer" that I first read about when MJ was diagnosed. I still remember the hope I had when I first read "Her2 had a poor prognosis before Herceptin". Now I can't help but think, what if it doesn't work in combination with other drugs for MJ? I saw a study that even when Herceptin is added to Tykerb, overall survival is only extended 4 months. Is it too much to want more than that? Sorry for the "blah" posting today. It's just how I'm feeling. ~Greg __________________ 08/10 ~ Dx IBC, Her2+++ ER-/PR- Stage 4, mets to liver. Age 43. 08/10 ~ Began 12 weeks of Taxetere/Carboplatin/Herceptin tx [10/10 ~ Scans show liver lesions are gone. NED! 11/10 ~ Ended chemo. Herceptin-only tx 01/11 ~ Mastectomy 03/11 ~ Radiation 07/11 ~ Reconstructive surgery 10/11 ~ PET/CT shows NED :) 01/12 ~ Malignant tumors found in uterus, cervix, fallopian tubes and lymph nodes. Dx as endometrial cancer. Stage III2c 02/12 ~Hysterectomy(all tumors removed). Back to NED. 02/12 ~ Final Herceptin treatment. 03/12 ~ Began Cisplatin/Adriamycin tx for endometrial cancer. 03/12 ~ Tumors dx her2 metastisis, not entdometrial cancer. Back to BC tx. 03/12 ~ CT scan shows NED. :) 04/12/~ Began Tykerb/Xeloda. 06/12 ~ Ended Xeloda. Continuing Tykerb. Still NED. 09/12 ~ PET/CT scans show NED. : ) 04/13 ~ Rash on original breast biopsied as cancer. 05/13 ~ Surgery to remove skin and tissue around rash. Continue Tykerb. 06/13 ~ PET/CT scans show NED : ) 11/13 ~ Jaundice eyes and skin. CT scan show mets to liver as well as peritoneal carcinomatosis with malignant ascites. Began Abraxane/Herceptin tx. 02/14 ~ CT scan shows NED. :)