|
Re: Breast cancer mets to Uterus
As Herceptin is a targeted therapy it may well be that the chemo is the drug that has become ineffective (my theory - maybe the resident tech gurus will chime in here) and that still blocking the Her2 receptor is useful in trying with a different combination/chemotherapy. Lani posted a great article which shows this although questions the economics of doing so.
If you look at the Stage4 survivors thread there are many, many, many women there some 10 years down the track who have used multiple chemos with herceptin with positive effect.
I am currently on Tykerb and Xeloda and experiencing a positive response so far - no other chemo combination has reduced my mets but this one has some of them gone in 9 weeks!
Your wife has many, many options. Given that she has had the hysterectomy are the tumours now gone? Were they retested for receptor status?
I too was resistant to anthracyclines but am responding to Tykerb and xeloda - I hope that your wife does too.
__________________
Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis
June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions
Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
|