Re: Tamoxifen, LHRH agonist, AI, oophorectomy??
I also want to add that in the "olden" days, they would know that a cancer was hormone positive but they did not know that it was also Her2+. So even though the Tamoxifen may have been doing its job, there was nothing to supress the Her2 receptor so that would make the cancer recur. At least the Tamoxifen and Herceptin combo prevents that so in reality, you do not need to make decisions until the Herceptin therapy is over as the Tamoxifen will take care of the hormone receptors and the Herceptin will take care of the Her2 receptors.
I think (imho) that olden day tumors were not necessarily resistant to Tamoxifen, its just that there were 2 devils to deal with and nothing was done about the Her2 so that just took over.
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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