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Sheila · 01-04-2012, 07:21 AM

As many of you know, my Mother had breast cancer, as well as a maternal cousin, myself, my youngest sister, and now a paternal cousin. My mother passed away from a new primary liver cancer a year ago. Needless to say, there has been a whole lot of testing going on, to see if there is a common link or gene....here are the results...

Mom - ER+ PR +, Her2 testing not done 24 yrs ago
Me - ER- PR- , Her2 +++ BRCA 1 & 2 Neg
M. Cousin - ER+, PR+, Her2 not done 17 years ago.
Sister - Triple Neg tumor and Triple Positive Tumor, BRCA 1 & 2 Neg
P. Cousin Triple Positive tumors (both sides) BRCA 1 & 2 NEG

So, we share some link, just unknown at this time....on the bright side, my sister finished her chemo last week and now is on Herceptin solo for the next 9 months...we were able to go together and get treated together her last chemo...which was special as she is every 3 weeks and me every 2....I am so happy she has completed her chemo and with very little side effects...she worked the entire time....must be her youth!

01-04-2012, 07:21 AM	#1
Sheila Senior Member Join Date: Aug 2003 Location: Morris, IL Posts: 3,507	Common Bond & Our Genetic Testing As many of you know, my Mother had breast cancer, as well as a maternal cousin, myself, my youngest sister, and now a paternal cousin. My mother passed away from a new primary liver cancer a year ago. Needless to say, there has been a whole lot of testing going on, to see if there is a common link or gene....here are the results... Mom - ER+ PR +, Her2 testing not done 24 yrs ago Me - ER- PR- , Her2 +++ BRCA 1 & 2 Neg M. Cousin - ER+, PR+, Her2 not done 17 years ago. Sister - Triple Neg tumor and Triple Positive Tumor, BRCA 1 & 2 Neg P. Cousin Triple Positive tumors (both sides) BRCA 1 & 2 NEG So, we share some link, just unknown at this time....on the bright side, my sister finished her chemo last week and now is on Herceptin solo for the next 9 months...we were able to go together and get treated together her last chemo...which was special as she is every 3 weeks and me every 2....I am so happy she has completed her chemo and with very little side effects...she worked the entire time....must be her youth! Attached Images __________________ "Be kinder than necessary, for everyone you meet is fighting some kind of battle." Hugs & Blessings Sheila Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications) Core Biopsy 2/22/02 L. Mastectomy 2/25/2002 Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg 6/2003 Reconstruction W/ Tissue Expander, Silicone Implant 9/2003 Stage IV with Mets to Supraclavicular nodes 9/2003 Began Herceptin every 3 weeks 3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes 3/2007 Added back the Xeloda with Herceptin for continued mets to nodes 5/2007 Taken Off Xeloda, no longer working 6/14/07 Taxol/Herceptin/Avastin 3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee 5/29 2008 Back on Taxol w Herceptin q 2 weeks 4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve 5/2009 Begin Rx with Navelbine/Herceptin 11/09 Progression on Navelbine Fought for and started Tykerb/Herceptin...nodes are melting!!!!! 2/2010 Back to Avastin/Herceptin 5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate Pericardial Window Surgery to Drain Pericardial Effusion 7/2010 Back to walking a mile a day...YEAH!!!! 9/2010 Nodes are back with a vengence in neck Qualified for TDM-1 EAP 10/6/10 Begin my miracle drug, TDM-1 Mixed response, shrinking internal nodes, progression skin mets after 3 treatments 12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments 2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!! 7/5/11 begin Gemzar /Herceptin for node progression 2/8/2012 Gemzar stopped, Continue Herceptin 2/20/2012 Begin Tomo Radiation to Neck Nodes 2/21/2012 I CELEBRATE 10 YEARS 5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression 6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin