Thread: It's official
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Old 01-02-2012, 06:55 AM   #14
Joan M
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Join Date: Oct 2007
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Re: It's official

You have many options to manage this disease.

I became stage 4 in Jan. 07 after being stage 2 in 03. I've been on only Herceptin since my disease advanced and NED since Oct 08, thus far a little over 3 years. The cancer was treated with local procedures, and these are options that most oncologist never mention and that many doctors disagree with.

The cancer spread to my lung and brain. I had a lung wedge resection in 07 and the cancer recurred there a year later. I then had radiofrequency ablation, or RFA, which burned the recurrence (cryoablation, as well as chemoembolization is also used to treat liver nodules).

In the same year, a brain met was discovered (I had no symptoms, but after my cancer became stage 4 my onc agreed to give me an annual brain MRI, and on the second scan, 16 months after the first, showed a nodule in my left frontal lobe). The nodule was treated with surgery (a craniotomy) followed 6 weeks later with 5 dosages of targeted radiation to the tumor bed (IMRT).

The lung nodule was HER2+ on biopsy before the surgery but my brain nodule was HER2-.

If you want more information about local procedures here's a link to a video from a conference I attended in October that was given my the Metastatic Breast Cancer Network at Johns Hopkins. See Dr. Hirose's presentation. That presentation, as well as all the others, was excellent and very informative.

http://mbcn.org/special-events/categ...presentations/

You have a lot of options. Stay strong. Praying for you.

Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!

Last edited by Joan M; 01-02-2012 at 07:00 AM..
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