HER2 Support Group Forums - View Single Post - brain changes associated w chemo induced cognitive dysfunction identified

Lani · 11-17-2011, 10:13 AM

I looked at the article.

It did NOT test them before surgery and then after surgery but before chemo or hormonal and then after chemo/hormonal and then periodically thereafter as you would need to to draw more meaningful conclusions

It just matched the numbers of those who got chemo and those who did not for hormonal therapy NOT EVEN CONSIDERING IT could be the antihormonal therapy that was responsible (not even in the discussion of possible confounders at the end of the article) and didn't reflect on the fact that one of the mechanisms of action/results of chemotherapy is to put patients in premature menopause ie, it might be the time course of estrogen deprivation which is important. It just matched the patients with and without chemo and without bc for age and menopausal status.

Lot of work left to be done!

11-17-2011, 10:13 AM	#9
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Re: brain changes associated w chemo induced cognitive dysfunction identified I looked at the article. It did NOT test them before surgery and then after surgery but before chemo or hormonal and then after chemo/hormonal and then periodically thereafter as you would need to to draw more meaningful conclusions It just matched the numbers of those who got chemo and those who did not for hormonal therapy NOT EVEN CONSIDERING IT could be the antihormonal therapy that was responsible (not even in the discussion of possible confounders at the end of the article) and didn't reflect on the fact that one of the mechanisms of action/results of chemotherapy is to put patients in premature menopause ie, it might be the time course of estrogen deprivation which is important. It just matched the patients with and without chemo and without bc for age and menopausal status. Lot of work left to be done!