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R.B. · 10-19-2011, 02:40 PM

More Omega 3 and 6 mechanisms which affect cancer cell function (-:

Omega 6 derivatives are the main natural activators of pathways in which cannabis derivatives are also active, which has a host of implications, including in controlling mood, food intake, weight gain etc. As well as influencing brain function these Omega 6 compounds are also active in many cells, including the reproductive system. This paper suggests they affect proliferation in cancer cells.

It looks as if Omega 3 derivatives have different roles in these pathways to Omega 6 derivatives and once again the balance between the two appears to affect cell function. ( FYI anandamide and 2-arachidonoylglycerol are omega 6 based products - see below)

The involvement of cannabis receptors begs the question does cannabis affect cancer (increase or decrease) by inhibiting the access of other compounds to these pathways - scientists are looking a the effects of cannabis derivatives on cancer - and that in turn would depend on the balance of natural activators produced in the body, including through the Omega 3 and 6 pathways but the wider implications ??? These receptors are found widely in the body including in the brain, and I value the function of mine.

Prostaglandins Leukot Essent Fatty Acids. 2011 Oct 11. [Epub ahead of print]
Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines.
Brown I, Wahle KW, Cascio MG, Smoum-Jaouni R, Mechoulam R, Pertwee RG, Heys SD.
Source

Translational Medical Sciences, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Abstract

Omega-3 (n-3) fatty acids inhibit breast and prostate cancer cell growth. We previously showed that N-acylethanolamine derivatives of n-3 (n-3-NAE) are endocannabinoids, which regulate cancer cell proliferation. These n-3-NAE are synthesised in certain cells/tissues, after supplementing with fatty acids, however, no one has assessed whether and to what extent this occurs in cancer cells. We determined levels of endogenous n-3-NAEs in hormone sensitive and insensitive prostate and breast cancer cells and subsequent effects on other endocannabinoids (anandamide and 2-arachidonoylglycerol), before and after supplementing with DHA and EPA fatty acids, using HPLC tandem mass spectrometry. This is the first study reporting that n-3-NAEs are synthesised from their parent n-3 fatty acids in cancer cells, regardless of tumour type, hormone status or the presence of fatty acid amide hydrolase. This could have important implications for the use of n-3 fatty acids as therapeutic agents in breast and prostate cancers expressing cannabinoid receptors.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21995886
[PubMed - as supplied by publisher]

10-19-2011, 02:40 PM	#3
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: The traditional diet of Greece and cancer. More Omega 3 and 6 mechanisms which affect cancer cell function (-: Omega 6 derivatives are the main natural activators of pathways in which cannabis derivatives are also active, which has a host of implications, including in controlling mood, food intake, weight gain etc. As well as influencing brain function these Omega 6 compounds are also active in many cells, including the reproductive system. This paper suggests they affect proliferation in cancer cells. It looks as if Omega 3 derivatives have different roles in these pathways to Omega 6 derivatives and once again the balance between the two appears to affect cell function. ( FYI anandamide and 2-arachidonoylglycerol are omega 6 based products - see below) The involvement of cannabis receptors begs the question does cannabis affect cancer (increase or decrease) by inhibiting the access of other compounds to these pathways - scientists are looking a the effects of cannabis derivatives on cancer - and that in turn would depend on the balance of natural activators produced in the body, including through the Omega 3 and 6 pathways but the wider implications ??? These receptors are found widely in the body including in the brain, and I value the function of mine. Prostaglandins Leukot Essent Fatty Acids. 2011 Oct 11. [Epub ahead of print] Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines. Brown I, Wahle KW, Cascio MG, Smoum-Jaouni R, Mechoulam R, Pertwee RG, Heys SD. Source Translational Medical Sciences, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, AB25 2ZD, UK. Abstract Omega-3 (n-3) fatty acids inhibit breast and prostate cancer cell growth. We previously showed that N-acylethanolamine derivatives of n-3 (n-3-NAE) are endocannabinoids, which regulate cancer cell proliferation. These n-3-NAE are synthesised in certain cells/tissues, after supplementing with fatty acids, however, no one has assessed whether and to what extent this occurs in cancer cells. We determined levels of endogenous n-3-NAEs in hormone sensitive and insensitive prostate and breast cancer cells and subsequent effects on other endocannabinoids (anandamide and 2-arachidonoylglycerol), before and after supplementing with DHA and EPA fatty acids, using HPLC tandem mass spectrometry. This is the first study reporting that n-3-NAEs are synthesised from their parent n-3 fatty acids in cancer cells, regardless of tumour type, hormone status or the presence of fatty acid amide hydrolase. This could have important implications for the use of n-3 fatty acids as therapeutic agents in breast and prostate cancers expressing cannabinoid receptors. Copyright © 2011 Elsevier Ltd. All rights reserved. PMID: 21995886 [PubMed - as supplied by publisher] Last edited by R.B.; 10-19-2011 at 02:46 PM..