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Old 09-19-2011, 02:34 AM   #44
kykeon22
Senior Member
 
Join Date: Aug 2011
Posts: 51
Re: Rare? Her2+, ER+, PR+

My mom was diagnosed triple positive too, 3 1/2 years ago. It's not rare, about 20 % of all breast tumors are triple positive. There are 4 subtypes according the ER, Pr and Her2 receptors. I found this article

http://ww5.komen.org/BreastCancer/Su...astCancer.html

it explains well the four subtypes. The progonosis of triple positve breast cancer is poorer than Hr pos and Her2 neg, but is better compared to the other two subtypes. The ER+ receptor are a good thing because it counterbalances the Her2 neu pos receptor. At one of our first visit the onco said this type of tumor though very aggressive (it grows faster than the other types) tend to respond well to treatments, and there are plenty of treaments. Endocrine therapy, Targeted therapy, and as a last resort Chemiotherapy. The downside, as said before, is the fact that this type of tumor has a high ki67 score, which means that the cells grow faster, thus the cancer must always be under greater check in order to change therapy as soon as possible when the prior one fails.
__________________
Son of Ha

She has been dignosed in February 2008 BC state IV, left breast multiple nodes size 5 cm, mets lungs and liver. Er+ Pr+ Her neu +++.
3/2008 - 10/2010 Herceptin + Aramidex NED
10/2010 recurrence lung met, pleural effusion, toracentesis
11/2010- Tyverb + Navalbine NED
08/2011 CA-15-3 = 90 scan
08/2011 Scan revealed reccurrence lung met, tiny metastasis on the pleura and pleural effusion.
4 pills tyverb, mytoxantrone once ever three weeks, and Aromasin.
Tykerb and taxol, sever allergic reaction
Tykerb taxotere
Herceptin, perjeta, gemcitabina
C- diff, bad diarrea
Halevan and tamoxifen, tm down from 1200 to 130

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