[Rich66]

Seems like Denosumab is definitely worth a try in your situation. As is weekly Zometa like my mom is getting..no neck pain after a bit on that regimen.

Just a thought on the hormonal side. You have had estrogen receptor blockers and aromatase inhibitors separately. There is a possibility that combining the two might help...i.e. Faslodex or Tamoxifen + Femara or Aromasin. Adding metformin..yeah..I know onc gave resistance..but onc should be more flexible if using phrases like running out of drugs etc.

Any chance to get a new biopsy/sample for chemosensitivity testing?

Is it thought that your reactions were due to her2 meds? Otherwise, seems like all indications suggest continuation of at least Herceptin beyond progression.