View Single Post
Old 08-26-2011, 01:01 PM   #8
fullofbeans
Senior Member
 
Join Date: Jan 2007
Location: UK
Posts: 617
Re: a plant extract with tested potency

Elaine the link you provide is about another species (Scutellaria baicalensis.) but from the same genera indeed the Sloane Ketting site warn about this:
"
Scutellaria barbata is a perennial herb prevalent in Korea and southern China. It is used along with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, tumors, and as a diuretic. It should not be confused with Scutellaria baicalensis.

Data from in vitro studies suggest that S. barbata has antibacterial (1), antimutagenic (2), and anticancer (3) (4) (5) (6) (7) (8) (10) (11) (12) properties. The flavonoid components are thought responsible for the anticancer activity. Small studies of S. barbata show that it is safe and may benefit patients with advanced breast cancer (13) (14). Further research is needed.
"
As you can see this plant has been used in the traditionally for treating people for tumors, ie the simple plant extract.

Yes indeed many drugs are from plants I guess most of us know about taxol but the difference with this thread is that this company is simply using an extract. Many drugs are not simple extract but most have twicked the molecular compound to provide medical acceptable dosage. Here the phenomena happening is that we are taking ancestral herbs/traditional medicine banning their use (by putting financial barriers) and re-introduce them for 100 time the prices. So no it does not matter who develop it but whether it cost 10p or 100$ a pill matter to vary many. whether you can have it now or in 10 years matter to stage 3 & 4. Synergy is also of relevance here many cannot afford to have many of these drug acting in synergy like tyk and herc. If there could be a way to have eased up rule for trials of safe compound such as this plant extract simply adding it to the standard of care of some patient it would be a good way forward.

Thanks for encouraging me to post when I think it may be of use. In a similar way thank you for your reply. And yes I agree about the need of patients first not bark from trees or for that matter mice (which require massive paper work and cost a lots to be used even in cancer drug development).


References
1-Sato Y, et al. Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus. J Ethnopharmacol 2000; 72(3):483-488.
2-Wong BY, Lau BH, Teel RW. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. Cancer Lett 1992; 62(2):123-131.
3-Wong BY, et al. Oldenlandia diffusa and Scutellaria barbata augment macrophage oxidative burst and inhibit tumor growth. Cancer Biother Radiopharm 1996; 11(1):51-56.
4-Chan JY, et al. Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells. Planta Med 2006; 72(1):28-33.
5-Goh D, Lee YH, Ong ES. Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. J Agric Food Chem 2005; 53(21):8197-8204.
6-Kim DI, et al. Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds. Toxicol Appl Pharmacol 2005; 205(3):213-224.
7-Yin X, et al. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sci 2004; 75(18):2233-2244.
8-Powell CB, et al. Aqueous extract of herba Scutellaria barbatae, a chinese herb used for ovarian cancer, induces apoptosis of ovarian cancer cell lines. Gynecol Oncol 2003; 91(2):332-340.
9-Chen JK, Chen TT. Chinese Medical Herbology and Pharmacology, 2nd ed. California: Art of Medicine Press; 2004.
10-Yu J, Liu H, Lei J, et al. Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytother Res. 2007 Sep;21(9):817-22.
11-Kim KW, Jin UH, Kim DI, et al. Antiproliferative effect of Scutellaria barbata D. Don. on cultured human uterine leiomyoma cells by down-regulation of the expression of Bcl-2 protein. Phytother Res. 2008 May;22(5):583-90.
12-Ozmen A, Madlener S, Bauer S, et al. In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. Phytomedicine. 2009 Jul 1. [Epub ahead of print].
13-Rugo H, Shtivelman E, Perez A, et al. Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Breast Cancer Res Treat. 2007 Sep;105(1):17-28. Epub 2006 Nov 17.
14-Perez AT, Arun B, Tripathy D, et al. A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat. 2010 Feb;120(1):111-8.
__________________

35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies

Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..

superior vena cava blocked: stent but face remains puffy

April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.

Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.



'Under no circumstances should you lose hope..' Dalai Lama

Last edited by fullofbeans; 08-26-2011 at 01:15 PM..
fullofbeans is offline   Reply With Quote