HER2 Support Group Forums - View Single Post - More information than they know what to do with

Joan M · 08-22-2011, 03:50 PM

This article discusses how using genetic testing in trials to find out which cancer drugs work early on for specific patients will cut down the length of time it takes for a drug to get to market and the cost of a drug -- in Britain, that is. The National Institute for Health and Clinical Excellence will not approve drugs that are too expensive for the return they offer (or as Fran Visco, President of the National Breast Cancer Coalition has said, breast cancer survivors have been conditioned to jump for joy if the FDA approves a drug that extends life by 4 months). The article mentions Herceptin. The ideas in the article are similar to the I-Spy trial.

Article;
http://www.guardian.co.uk/science/20...rch-golden-era

I-Spy trial
http://ncicb.nci.nih.gov/tools/trans..._research/ispy

Joan

08-22-2011, 03:50 PM	#7
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Re: More information than they know what to do with This article discusses how using genetic testing in trials to find out which cancer drugs work early on for specific patients will cut down the length of time it takes for a drug to get to market and the cost of a drug -- in Britain, that is. The National Institute for Health and Clinical Excellence will not approve drugs that are too expensive for the return they offer (or as Fran Visco, President of the National Breast Cancer Coalition has said, breast cancer survivors have been conditioned to jump for joy if the FDA approves a drug that extends life by 4 months). The article mentions Herceptin. The ideas in the article are similar to the I-Spy trial. Article; http://www.guardian.co.uk/science/20...rch-golden-era I-Spy trial http://ncicb.nci.nih.gov/tools/trans..._research/ispy Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!! Last edited by Joan M; 08-22-2011 at 03:54 PM..