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Re: once or twice daily oral irreversible egfr AND her2 inhibitor being developed inC
Elly it is in Phase 1 in China already. Yes I love the fact that little regulation allow for fast progress in that country. If only things were carried out with the type of professionalism we can find in the west (which hopefully they will improve on and learn not to cut corners as much) we will all go there pretty soon as oppose to be on the most toxic drug possible licensed 25 to 50 years ago on the basis that there are too many risk trialling these apparently much less toxic products..
From their paper: "Our data establish AST1306, which is currently in phase I clinical trial in China, as a novel irreversible ErbB inhibitor that deserves further development."
I share my views with the father of the DNA discovery:
James Watson: 'cancer research is over regulated'
http://www.guardian.co.uk/science/20...ancer-research
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35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies
Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..
superior vena cava blocked: stent but face remains puffy
April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.
Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.
'Under no circumstances should you lose hope..' Dalai Lama
Last edited by fullofbeans; 07-30-2011 at 01:17 PM..
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