[Rich66]

"emerging evidence shows many of the drugs like Avastin may be just as effective and produce fewer side effects if taken over shorter periods and in lower doses."

Have to wonder how many drugs are either discarded or approved in a limited benefit dose due to bias towards "more is better". Phase one is usually focused on determining how much is physiologically tolerable..only after they determine that amount do they determine how well the drug works. There is now significant suggestion that drugs can sometimes be used at highest dose and metronomic dose with benefit in each instance..i.e. 2 for 1.