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Joan M · 06-29-2011, 07:01 AM

Michka,

Cement? Never heard of that one.

8mm is pretty small, which is good.

I sent you a PM with the contact information of the medical oncologist in Manhattan who authorized my friend's procedure.

I don't know anything about Zometa and Denusumab. Why can't the dentist just drill the cavity and fill it?

I recently had a root canal and will be getting a permanent cap on Friday. But on Monday, I was eating popcorn and broke one of my premolars, so I'm looking at another root canal and cap. The first one was to fill a large space that was irritating me, but too big to just replace and ancient filling. The broken tooth hurts when I chew.

I do not want my teeth pulled because my cancer cells could be lurking in my bone marrow, which is just one of the theories about where dormant exist. I don't want to take a chance. But here's an e-mail exchange that I recently had with a scientist in Philadelphia which mentions this topic:

Dear Joan,
I'm sorry for delayed reply. I've missed your message, because guestbook messages are not re-directed to my email box.
Thanks for your attention to my blog and for sharing your personal story.
Unfortunately I have no experience in clinical oncology. I have a personal interest in cancer stem cell research and I'm teasing out this a little in my leukemia experiments.
I think local procedures for prevention metastasis could help some patients, but there will be no guarantee. It's clear now that malignant cells could undergo dormancy and stay in this condition for years. We don't know what trigger their activation. It's big unknown right now. Some researchers associate cancer dormancy with cancer stem cells, but it's just a theory.
There are many new interesting experimental approaches proposed in the last 3 years for inhibiting metastatic process. Some of them were proposed for clinical trials.
According your question about a tooth. Nobody knows right now what can instigate dormant cancer cells. There are very few research done, which show that cancer cells can undergo dormancy in bone marrow. And if they stay in bone marrow, we have no idea in what bones (maybe never in jaw). As far as I know it's very much unclear where dormant cancer cells can hide in the body.* So, I'd advice you to go ahead and pull your tooth.
*******

Joan

06-29-2011, 07:01 AM	#13
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Re: Cyberknife and sternum Michka, Cement? Never heard of that one. 8mm is pretty small, which is good. I sent you a PM with the contact information of the medical oncologist in Manhattan who authorized my friend's procedure. I don't know anything about Zometa and Denusumab. Why can't the dentist just drill the cavity and fill it? I recently had a root canal and will be getting a permanent cap on Friday. But on Monday, I was eating popcorn and broke one of my premolars, so I'm looking at another root canal and cap. The first one was to fill a large space that was irritating me, but too big to just replace and ancient filling. The broken tooth hurts when I chew. I do not want my teeth pulled because my cancer cells could be lurking in my bone marrow, which is just one of the theories about where dormant exist. I don't want to take a chance. But here's an e-mail exchange that I recently had with a scientist in Philadelphia which mentions this topic: Dear Joan, I'm sorry for delayed reply. I've missed your message, because guestbook messages are not re-directed to my email box. Thanks for your attention to my blog and for sharing your personal story. Unfortunately I have no experience in clinical oncology. I have a personal interest in cancer stem cell research and I'm teasing out this a little in my leukemia experiments. I think local procedures for prevention metastasis could help some patients, but there will be no guarantee. It's clear now that malignant cells could undergo dormancy and stay in this condition for years. We don't know what trigger their activation. It's big unknown right now. Some researchers associate cancer dormancy with cancer stem cells, but it's just a theory. There are many new interesting experimental approaches proposed in the last 3 years for inhibiting metastatic process. Some of them were proposed for clinical trials. According your question about a tooth. Nobody knows right now what can instigate dormant cancer cells. There are very few research done, which show that cancer cells can undergo dormancy in bone marrow. And if they stay in bone marrow, we have no idea in what bones (maybe never in jaw). As far as I know it's very much unclear where dormant cancer cells can hide in the body.* So, I'd advice you to go ahead and pull your tooth. ******* Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!! Last edited by Joan M; 06-29-2011 at 07:04 AM..