[Rich66]

Mom had it done a couple times. It was alittle weird from eth beginning since the lab used seemed to have a different cutoff point (lower) than typical. It was slightly elevated according to that cutoff. And it did go down after first Herceptin. And she did hold on just Herceptin for a bit. So I guess teh slight elevation was used as justification for trying Herceptin despite a borderline but considered negative FISH result. Considering Herceptin held her for some time, seems to suggest some level of Her2 activity. Papers being flung back and forth since have put into question the utilityof serum her2. But again..I wish I could remember who was using serum Her2 as a barometer for when to get back on Herceptin. I think I read somewhere along the line that there may be different ways to measure serum her2 so maybe the idea has validity but the test is imperfect. I guess it was of value to mom in that it allowed an experiment with Herceptin that probably couldn't have been justified otherwise. I think of it as a tool in the toolbox that may or not be helpful. Probably one of those things that shows value, if it has any for a given patient, over time.