HER2 Support Group Forums - View Single Post - for those w brain mets--once again remaining on herceptin improves prognosis but this

Lani · 06-08-2011, 06:29 PM

Jackie--actually lapatinib is a her1 (EGFR)/her2 dual receptor tyrosine kinase inhibitor. Since her3 likes to form dimers with her1, her2 and her4, blocking her1 and her2 leaves less hers available for her3 to form dimers with and as it lacks its own phosphorylation site, it needs to couple with some other her to act.

06-08-2011, 06:29 PM	#8
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Re: for those w brain mets--once again remaining on herceptin improves prognosis but Jackie--actually lapatinib is a her1 (EGFR)/her2 dual receptor tyrosine kinase inhibitor. Since her3 likes to form dimers with her1, her2 and her4, blocking her1 and her2 leaves less hers available for her3 to form dimers with and as it lacks its own phosphorylation site, it needs to couple with some other her to act.