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R.B. · 05-15-2011, 03:58 PM

In essence the fat composition of the breast tissue is diet sensitive.

A trial looking at the impact of dietary EPA + DHA suggests that in terms of tissue composition there was not any significant benefit in more that 2.52 grams a day.

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http://www.ncbi.nlm.nih.gov/pmc/arti...tool=pmcentrez

ω-3 Fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition1,2,3
Lisa D Yee,corresponding author Joanne L Lester, Rachel M Cole, Julia R Richardson, Jason C Hsu, Yan Li, Amy Lehman, Martha A Belury, and Steven K Clinton

Background: Preclinical evidence of the preventive benefits of ω-3 (n–3) polyunsaturated fatty acids (PUFAs) in breast cancer continues to fuel interest in the potential role of dietary fat content in reducing breast cancer risk. The dose of fish-oil/ω-3 PUFAs needed to achieve maximal target tissue effects for breast cancer prevention remains undefined.
Objective: To determine the dose effects of ω-3 fatty acids on breast adipose tissue fatty acid profiles, we conducted a study of 4 doses of ω-3 PUFAs in women at high risk of breast cancer.
Design: In this 6-mo randomized open-label study, 48 women with increased breast cancer risk received 1, 3, 6, or 9 capsules/d of an ω-3 PUFA supplement that provided 0.84, 2.52, 5.04, and 7.56 g docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) daily, respectively. Subjects made monthly visits, at which time pill counts were made and fasting blood samples were collected to determine fatty acid profiles; anthropometric measurements were made, breast adipose tissue samples were collected, and laboratory tests of toxicity (alanine aminotransferase, LDL cholesterol, and platelet function) were made at baseline and at 3 and 6 mo.
Results: All doses led to increased serum and breast adipose tissue EPA and DHA concentrations, but the response to 0.84 g DHA+EPA/d was less than the maximum possible response with ≥2.52 g/d. Body mass index attenuated the dose response for serum tissue DHA and EPA (P = 0.015 and 0.027, respectively) and breast adipose tissue DHA (P = 0.0022) in all of the treatment groups. The incremental increase in DHA and EPA correlated inversely with baseline fat and serum values. Compliance over 6 mo was 92.9 ± 9.2% and was unaffected by treatment arm. No severe or serious toxicities were reported.

Conclusions: Daily doses up to 7.56 g DHA+EPA were well tolerated with excellent compliance in this cohort at high risk of breast cancer. Body mass index and baseline fatty acid concentrations modulated the dose-response effects of ω-3 PUFA supplements on serum EPA and DHA and breast adipose tissue DHA.

05-15-2011, 03:58 PM	#345
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: The traditional diet of Greece and cancer. In essence the fat composition of the breast tissue is diet sensitive. A trial looking at the impact of dietary EPA + DHA suggests that in terms of tissue composition there was not any significant benefit in more that 2.52 grams a day. Full Free Text http://www.ncbi.nlm.nih.gov/pmc/arti...tool=pmcentrez ω-3 Fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition1,2,3 Lisa D Yee,corresponding author Joanne L Lester, Rachel M Cole, Julia R Richardson, Jason C Hsu, Yan Li, Amy Lehman, Martha A Belury, and Steven K Clinton Background: Preclinical evidence of the preventive benefits of ω-3 (n–3) polyunsaturated fatty acids (PUFAs) in breast cancer continues to fuel interest in the potential role of dietary fat content in reducing breast cancer risk. The dose of fish-oil/ω-3 PUFAs needed to achieve maximal target tissue effects for breast cancer prevention remains undefined. Objective: To determine the dose effects of ω-3 fatty acids on breast adipose tissue fatty acid profiles, we conducted a study of 4 doses of ω-3 PUFAs in women at high risk of breast cancer. Design: In this 6-mo randomized open-label study, 48 women with increased breast cancer risk received 1, 3, 6, or 9 capsules/d of an ω-3 PUFA supplement that provided 0.84, 2.52, 5.04, and 7.56 g docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) daily, respectively. Subjects made monthly visits, at which time pill counts were made and fasting blood samples were collected to determine fatty acid profiles; anthropometric measurements were made, breast adipose tissue samples were collected, and laboratory tests of toxicity (alanine aminotransferase, LDL cholesterol, and platelet function) were made at baseline and at 3 and 6 mo. Results: All doses led to increased serum and breast adipose tissue EPA and DHA concentrations, but the response to 0.84 g DHA+EPA/d was less than the maximum possible response with ≥2.52 g/d. Body mass index attenuated the dose response for serum tissue DHA and EPA (P = 0.015 and 0.027, respectively) and breast adipose tissue DHA (P = 0.0022) in all of the treatment groups. The incremental increase in DHA and EPA correlated inversely with baseline fat and serum values. Compliance over 6 mo was 92.9 ± 9.2% and was unaffected by treatment arm. No severe or serious toxicities were reported. Conclusions: Daily doses up to 7.56 g DHA+EPA were well tolerated with excellent compliance in this cohort at high risk of breast cancer. Body mass index and baseline fatty acid concentrations modulated the dose-response effects of ω-3 PUFA supplements on serum EPA and DHA and breast adipose tissue DHA.