[Del]

Hi Adriana,
I am also on T-DM1, and my liver enzymes both rose like crazy (both AST and ALT). They were so high that I had to be reduced to a lower dose after my first treatment, and they were scared they would have to reduce the dosage again. Thankfully they have come down finally to just above normal, although I do have to stay on the initially reduced dose. And I have not had liver mets during treatment (they have not come back after my initial treatment in 2007, they are in my armpit lymph nodes now). My doctor had me stop all vitamins/supplements to try to reduce the enzyme levels, and I even had a liver biopsy, although that didn't show anything. I'm not sure why the numbers finally came down, it did take several months. At my last visit the nurse said it could have been that I had a virus.