HER2 Support Group Forums - View Single Post - need to attack her family receptors on multiple fronts for best efficacy

Lani · 03-11-2011, 11:25 PM

Trish--sorafinib is one of those tyrosine kinase inhibitors which are taken as pills. It is active against several angiogenic factors like VEGF (many TKIs are "promiscuous" ie, act on several targets rather than one specific target exclusively

mTor inhibitors work further down the pathway, examples are everolimus among others (two are I believe FDA approved for treating kidney cancer and for lining stents to keep blood vessels open)

Sorafinib is not an mTOr inhibitor, but rather a TKI which works against VEGFR and PDGFR and Raf kinase

Michka--yes, that means increasing her3 is one means by which a her2+ bc can evade tykerb (but not the only one). As usual cancer is a tricky thing, so it is best to block several of its means of escape

Hope this helped!

03-11-2011, 11:25 PM	#13
Lani Senior Member Join Date: Mar 2006 Posts: 4,782	Re: need to attack her family receptors on multiple fronts for best efficacy Trish--sorafinib is one of those tyrosine kinase inhibitors which are taken as pills. It is active against several angiogenic factors like VEGF (many TKIs are "promiscuous" ie, act on several targets rather than one specific target exclusively mTor inhibitors work further down the pathway, examples are everolimus among others (two are I believe FDA approved for treating kidney cancer and for lining stents to keep blood vessels open) Sorafinib is not an mTOr inhibitor, but rather a TKI which works against VEGFR and PDGFR and Raf kinase Michka--yes, that means increasing her3 is one means by which a her2+ bc can evade tykerb (but not the only one). As usual cancer is a tricky thing, so it is best to block several of its means of escape Hope this helped!