[Lani]

I think I might have confused some people

leptomeningeal carcinomatosis are too many to count mets on the linings of the brain, not the brain tissue itself

It is a rare complication so it is nice to see a report of a successful treatment

I think some interpreted my "translation" of carcinomatosis as too many mets to count as being too many brain mets to count.

This article applies to leptomeningeal (lining tissue of the brain) metastasis NOT brain parencyma (brain tissue itself) metastasis as the way the intrathecal therapy works is to mix with the CSF (cerebrospinal fluid) and bathe the lining tissue of the brain and thus have access to it.

Brain mets are as I understand it usually within the parenchyma (brain tissue itself) not near the surface or the linings of the brain and so the herceptin might not be able to penetrate to get access to the met and work

Hope this helps