HER2 Support Group Forums - View Single Post - Her 2 and Her 3 signalling and Dr M Moasser

Lani · 01-13-2011, 07:22 PM

blocking her2 is not necessarily a cure for all her2+ breast cancers for the Ireasons I listed above and others, such as upregulation of EGFR, IGFR1 etc.

Blocking her2 and her3 or blocking egfr, her2 and her3 may be a cure for a subgroup of her2+ breast cancers especially done so quickly that the tumor does not have time to find another signalling pathway to get around the blockade.

THere are drugs which block her3 which are used by researchers and in some clinical trials. Dr Ulrich, who got the AACR lifetime achievement award for herceptin (he did the work at Genentech) believes blocking her3 will be the most beneficial and effective way to work towards curing her2+ breast cancer.

Am not quite sure what you mean re Dr. Moasser's work, but if you are referring to giving the doses more intermittently rather than continuously to decrease the side effects, I would have to reread any articles to form an opinion. Obviously it would be nice for patient to go for longer periods without diarrhea!!

01-13-2011, 07:22 PM	#17
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Re: Her 2 and Her 3 signalling and Dr M Moasser blocking her2 is not necessarily a cure for all her2+ breast cancers for the Ireasons I listed above and others, such as upregulation of EGFR, IGFR1 etc. Blocking her2 and her3 or blocking egfr, her2 and her3 may be a cure for a subgroup of her2+ breast cancers especially done so quickly that the tumor does not have time to find another signalling pathway to get around the blockade. THere are drugs which block her3 which are used by researchers and in some clinical trials. Dr Ulrich, who got the AACR lifetime achievement award for herceptin (he did the work at Genentech) believes blocking her3 will be the most beneficial and effective way to work towards curing her2+ breast cancer. Am not quite sure what you mean re Dr. Moasser's work, but if you are referring to giving the doses more intermittently rather than continuously to decrease the side effects, I would have to reread any articles to form an opinion. Obviously it would be nice for patient to go for longer periods without diarrhea!!