HER2 Support Group Forums - View Single Post - Her 2 and Her 3 signalling and Dr M Moasser

Lani · 01-13-2011, 04:05 PM

No Ellie. It is a better predictor of minimal residual disease, future recurrence than CTCs and when her2+ the bone marrow cells (DTCs) are much better able to predict recurrence than when her2-. It seems her2+ patients rarely have her2- DTCs in their bone marrow, but her2-s may have her2+ cells, especially after they have been treated with antihormonals or chemos (ie, their cancer tries to switch to increase her signalling in order to survive the onslaught of chemos)

Remember these cells may be very slowly dividing and more difficult to eradicate with chemo therefore and may represent the cancer stem cells responsible for recurrences, if you adhere to the stem cell theory of breast cancer, which i do.

01-13-2011, 04:05 PM	#12
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Re: Her 2 and Her 3 signalling and Dr M Moasser No Ellie. It is a better predictor of minimal residual disease, future recurrence than CTCs and when her2+ the bone marrow cells (DTCs) are much better able to predict recurrence than when her2-. It seems her2+ patients rarely have her2- DTCs in their bone marrow, but her2-s may have her2+ cells, especially after they have been treated with antihormonals or chemos (ie, their cancer tries to switch to increase her signalling in order to survive the onslaught of chemos) Remember these cells may be very slowly dividing and more difficult to eradicate with chemo therefore and may represent the cancer stem cells responsible for recurrences, if you adhere to the stem cell theory of breast cancer, which i do.