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Chelee · 11-27-2010, 10:24 PM

Steph,
Is your friend switching from Zometa to Denosumab? Was this her onc's decision, or did your friend request to try it? Since the hard data has been so good on D I thought I would see alot of women already on this. But as Debbie just said we are still in the early days. I've done quite a bit of reading on this drug today and it still has most of the same SE's that Zometa has. Other then it did say there are no concerns about renal safety with denosumab like there is with Zometa. (That's a plus.) The risk of ONJ is similar with both drugs. One article says the D will come with a much higher price tag monthly. That could influence which drugs our onc's chooses in some cases.

Debbie, great post as I couldn't agree with you more. I've always been hesitate to try newer drugs till they have been out a while. I'm just waiting to see how many of our onc's start switching us over to denosumab now that is has the go ahead?

Chelee

11-27-2010, 10:24 PM	#4
Chelee Senior Member Join Date: Feb 2006 Location: Southern, CA Posts: 2,511	Re: Denosumab? Steph, Is your friend switching from Zometa to Denosumab? Was this her onc's decision, or did your friend request to try it? Since the hard data has been so good on D I thought I would see alot of women already on this. But as Debbie just said we are still in the early days. I've done quite a bit of reading on this drug today and it still has most of the same SE's that Zometa has. Other then it did say there are no concerns about renal safety with denosumab like there is with Zometa. (That's a plus.) The risk of ONJ is similar with both drugs. One article says the D will come with a much higher price tag monthly. That could influence which drugs our onc's chooses in some cases. Debbie, great post as I couldn't agree with you more. I've always been hesitate to try newer drugs till they have been out a while. I'm just waiting to see how many of our onc's start switching us over to denosumab now that is has the go ahead? Chelee __________________ DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes. Rt. MRM on 1-3-06 -- No Rads due to compromised lungs. Chemo started 2-7-06 -- TCH - - Finished 6-12-06 Finished yr of wkly herceptin 3-19-07 3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07 9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV. 9-28-09 Loading dose of Herceptin & started Zometa 9-29-09 Power Port Placement 10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head. 11-19-09 RT. Femur surgery - Rod placed 12-7-09 Navelbine added to Herceptin/Zometa. 3-23-10 Ten days of rads to RT femur. Completed. 4-05-10 Quit Navelbine--Herceptin/Zometa alone. 5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy. Results to FISH was unsuccessful--this happens less then 2% of the time. 7-7-10 Recurrence to RT axilla again. Back to UCLA for options.