HER2 Support Group Forums - View Single Post - Intro - and Herceptin and Tykerb for 30 yeard old with stage iv, mets to liver

Lani · 10-18-2010, 10:14 AM

Doubt you'll find a trial protocol for it combined with your other drugs, but Dr. Slamon thinks Faslodex works best in her2+er+s as it works via a different mechanism than AIs. It actually causes the estrogen receptors to be degraded PERMANENTLY on all cells it reaches (whether or not that includes the brain is a topic I have researched several times--the manufacturer did not seem to know). If/when one stops taking it, all new cells made after that time will have ERs, but as you don't make a lot of new brain cells, this topic seems "rather important"

It is approved for those who fail other antihormonal treatments, so just keep this info in mind.

It does not seem to have significantly more side effects than AIs and it is only given by shot once a month.

Just fyi

10-18-2010, 10:14 AM	#10
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: Intro - and Herceptin and Tykerb for 30 yeard old with stage iv, mets to liver Doubt you'll find a trial protocol for it combined with your other drugs, but Dr. Slamon thinks Faslodex works best in her2+er+s as it works via a different mechanism than AIs. It actually causes the estrogen receptors to be degraded PERMANENTLY on all cells it reaches (whether or not that includes the brain is a topic I have researched several times--the manufacturer did not seem to know). If/when one stops taking it, all new cells made after that time will have ERs, but as you don't make a lot of new brain cells, this topic seems "rather important" It is approved for those who fail other antihormonal treatments, so just keep this info in mind. It does not seem to have significantly more side effects than AIs and it is only given by shot once a month. Just fyi