[AlaskaAngel]

I'm puzzling it out too.

(I'm a hybrid of sorts, having used tamoxifen for 1 3/4 years but with no AI use -- and then having done the testosterone trial, with continuing to use the compounded testosterone cream per the 2004 Mayo clinic trial intermittently, including at present.)

My desire for the use of the testosterone was partly to help add back in some of the bodily muscle percentage that was lost during chemotherapy, which then helps to put more muscle "pull" back against the bones for weightbearing, and that helps to keep the bones healthier. My interpretation of the 2004 trial was that it was really too brief to gather good info (each person actually received the testosterone for just 4 weeks, with blinded crossover to or from none). At the time the concern was that the testosterone might contribute to the estradiol level. The 2004 trial was intended primarily to measure any return of sensuality/sexuality as well as mood, but not muscle/bone balance. And there was no identification of use of AI or not in that trial.

I know Vic has also been interested in the past.

I wonder if there is some element of positive result happening here in regard to reduction of AI pain that is related to restoration of better (healthier) muscle/bone balance.

A.A.

P.S. I wonder what the ages of those in the study were, in terms of how postmenopausal/menopausal/premenopausal status changes the effect, with the AI. I gather that a majority were more than 5 years out from treatment, but that still could put the majority under age 55, and yet the majority of breast cancer patients are over 55.