[Debbie L.]

This is very interesting. Good catch, Lani.

It has always seemed to me that with Tamoxifen, local estrogen supplementation (vaginal creams, suppositories, or ring) might be okay because the Tamoxifen would block any systemic uptake, particularly in the breast.

For an AI, it would seem that would not work in the breast (to supplement with estrogen, feeling safe because of the AI), because the AI doesn't affect already-present estradiol.

But I hadn't thought it thru, for things upstream of an estradiol (like testosterone), combined with an AI. I'm still not clear on why testosterone, un-converted, would help with menopausal symptoms, but if it does, that seems really important!

Thinking, thinking, and tending toward getting excited, too. What do you think, Lani, AA, and others? Am I missing something?

Debbie Laxague