HER2 Support Group Forums - View Single Post - guide to reading articles: what cell line types represent which bc subtypes

das · 08-12-2010, 05:48 PM

Hi, I am new to this literature, it is very interesting. For example some of the studies by Pegram showing synergistic effects of the combination of cisplatin/carboplatin and herceptin used MCF7 human breast cancer xenografts in athymic mice. From this new paper these breast cancer cells are not classified as HER2+ but as Luminal A and only weakly express HER2. Is that correct and what are the implications?

08-12-2010, 05:48 PM	#4
das Senior Member Join Date: Jul 2010 Posts: 28	Re: guide to reading articles: what cell line types represent which bc subtypes Hi, I am new to this literature, it is very interesting. For example some of the studies by Pegram showing synergistic effects of the combination of cisplatin/carboplatin and herceptin used MCF7 human breast cancer xenografts in athymic mice. From this new paper these breast cancer cells are not classified as HER2+ but as Luminal A and only weakly express HER2. Is that correct and what are the implications? __________________ IDC 6/2010 ER+PR+HER2+ Lumpectomy & SNB 0/2 nodes 2.7cm