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Chelee · 07-18-2010, 01:28 AM

I met with Dr. Hurvitz and she is just like Marcia described her...positive and upbeat. She has one trial she spoke to me about which is a randomized , muliticenter, phase III trial with TDM-1 VS Capecitabine + Lapatinib. My main interest is TDM-1...I really don't want to do Tykerb/Xeloda.

I realize it's a 50/50 chance of getting the TDM-1...but I'd hate to wait and go thru this whole process and end up with Tykerb/Xeloda. I was surprised I was offered this trial because Dr. Slamon told me at a prior visit he did not want me on chemo. But she explained that the TDM-1 trials are over and this is now phase III. They now want to see which combo works better for women with MBC. I was hoping to discuss other options since my recurrence is only in the one node...but her main interest is the trial which she is very excited about. I hate all the decisions we have to make regarding trt options. (Mentally it's exhausted.) Speaking for myself of course. lol

Chelee

07-18-2010, 01:28 AM	#26
Chelee Senior Member Join Date: Feb 2006 Location: Southern, CA Posts: 2,511	Re: It's back... I met with Dr. Hurvitz and she is just like Marcia described her...positive and upbeat. She has one trial she spoke to me about which is a randomized , muliticenter, phase III trial with TDM-1 VS Capecitabine + Lapatinib. My main interest is TDM-1...I really don't want to do Tykerb/Xeloda. I realize it's a 50/50 chance of getting the TDM-1...but I'd hate to wait and go thru this whole process and end up with Tykerb/Xeloda. I was surprised I was offered this trial because Dr. Slamon told me at a prior visit he did not want me on chemo. But she explained that the TDM-1 trials are over and this is now phase III. They now want to see which combo works better for women with MBC. I was hoping to discuss other options since my recurrence is only in the one node...but her main interest is the trial which she is very excited about. I hate all the decisions we have to make regarding trt options. (Mentally it's exhausted.) Speaking for myself of course. lol Chelee __________________ DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes. Rt. MRM on 1-3-06 -- No Rads due to compromised lungs. Chemo started 2-7-06 -- TCH - - Finished 6-12-06 Finished yr of wkly herceptin 3-19-07 3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07 9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV. 9-28-09 Loading dose of Herceptin & started Zometa 9-29-09 Power Port Placement 10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head. 11-19-09 RT. Femur surgery - Rod placed 12-7-09 Navelbine added to Herceptin/Zometa. 3-23-10 Ten days of rads to RT femur. Completed. 4-05-10 Quit Navelbine--Herceptin/Zometa alone. 5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy. Results to FISH was unsuccessful--this happens less then 2% of the time. 7-7-10 Recurrence to RT axilla again. Back to UCLA for options.