I've always taken my arimidex at lunchtime, I began so I'd remember to take it and the habit stuck!
Thankfully other than some joint stiffness I don't have any unmangable side effects and hope to continue on it after my five years are completed.
However, I do find it's become easier to tolerate the longer I've been on it, either that or I've just become used to it and don't remember normal anymore!