[Lani]

As I understand it Denosumab has only been FDA approved for osteoporosis for less than a month it seems. It is not FDA approved for breast and prostate cancer metastases, where it remains in clinical trials. In fact I seem to remember the FDA returning the drug to the company for more work before approval for prostate cancer.

It appears so far to be more effective than Zometa for osteoporosis(and may also be so for breast cancer), but has not been used in a large enough number of patients to have worked out all its side effects.

It may or may not have the additional antitumor effects that bisphosphonates have (or it may have others) as it is in an entirely different class of drugs, working in a totally different way.

It seems your doctor is recommending off-label use. The statistics are not yet in to do a full cost/benefit analysis of his/her suggestion, so it has more to do with your level of comfort.

Feel free to go to Amgen's website and try to look up the product information about side effects so far etc.

Good luck!