HER2 Support Group Forums - View Single Post - exciting preclinical finding re metformin (diabetes drug) killing cancer stem cell

1rarebird · 05-30-2010, 11:00 AM

Apparently, there is at least one trial coming soon. (See http://www.cancer.gov/clinicaltrials/CAN-NCIC-MA.32 ) It is designed for early stage breast cancer and is a large US/Canadian phase III trial that has been approved but is not active as of 5/27/07. One media account predicts recruiting as early as July this year. ( http://www.scrippsnews.com/content/c...ancer-patients ) Although for early stage, perhaps it will quickly lead to findings that will encourage more trials or clinical use for later stages. Even without those trials, doctors may be more likely to use Metformin in later stage settings given its low cost and extensive safety history.

bird

05-30-2010, 11:00 AM	#12
1rarebird Senior Member Join Date: Feb 2010 Location: TN Posts: 175	Re: exciting preclinical finding re metformin (diabetes drug) killing cancer stem cel Apparently, there is at least one trial coming soon. (See http://www.cancer.gov/clinicaltrials/CAN-NCIC-MA.32 ) It is designed for early stage breast cancer and is a large US/Canadian phase III trial that has been approved but is not active as of 5/27/07. One media account predicts recruiting as early as July this year. ( http://www.scrippsnews.com/content/c...ancer-patients ) Although for early stage, perhaps it will quickly lead to findings that will encourage more trials or clinical use for later stages. Even without those trials, doctors may be more likely to use Metformin in later stage settings given its low cost and extensive safety history. bird __________________ Male Breast Cancer, DX 5/15/09, IDC, STAGE 1, 1.7 cm, HER2+++, ER+(95%)/PR+(75%), Ki67 40%, grade 3, 0/5 nodes, TX: mastectomy, TCH finished 7/19/10, radiation 6 wks., Tamoxifen on going, bisphosphonate 24 mos.