[schoonder]

Roche is about to conduct a 1L mBC phase III study, one arm of this 3-arm evaluation is t-dm1 in combo with pertuzumab. Link points to details of that trial. http://www.clinicaltrials.gov/ct2/show/NCT01120184?term=marianne+pertuzumab&rank=1
An on-going phase 1b t-dm1 trial in combo with paclitaxel (and pertuzumab, if applicable) is still recruiting candidates. http://www.clinicaltrials.gov/ct2/show/NCT00951665?term=pertuzumab+mcc&rank=2
An expanded single agent t-dm1 phase II evaluation recently got underway in Florida. More sites to follow
http://www.clinicaltrials.gov/ct2/show/NCT01120561?term=t-dm1&rank=8