[Hopeful]

Something that puzzles me is that I thought that inflammation was a pro-cancer process, and these drugs induce inflammation in some people. Would that not be a contra-indication to taking this class of drug in and of itself?

I also like the subtlty of the following quote from the article:

"The most significant predictors for stopping therapy were a previous history of taking tamoxifen, which can also cause arthralgia and other symptoms; having other inflammatory conditions such as arthritis; communication about difficulties with taking AIs, and being married." (emphasis added).

Being married, I infer, is a euphemism for "being sexually active," which is most definitely a challenge on these drugs.

Hopeful