HER2 Support Group Forums - View Single Post - Inhibition of phosphatidylcholine-specific phospholipase C depletes her2 receptors

Lani · 05-13-2010, 01:32 AM

via multiple mechanisms

her2+ breast cancer cells have 2 million her2 receptors per cell, whereas normal cells have only 2 or 3, according to Dr Slamon

seems to be more effective vs. ER- than ER+ her2+ cell lines(SkBr3 vs BT474)

question is how safe it might be, but in at least one study in mice it seemed not to affect them adversely in any measurable way

Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells

http://breast-cancer-research.com/co...df/bcr2575.pdf

05-13-2010, 01:32 AM	#1
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Inhibition of phosphatidylcholine-specific phospholipase C depletes her2 receptors via multiple mechanisms her2+ breast cancer cells have 2 million her2 receptors per cell, whereas normal cells have only 2 or 3, according to Dr Slamon seems to be more effective vs. ER- than ER+ her2+ cell lines(SkBr3 vs BT474) question is how safe it might be, but in at least one study in mice it seemed not to affect them adversely in any measurable way Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells http://breast-cancer-research.com/co...df/bcr2575.pdf