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Chelee · 02-26-2010, 09:32 PM

Julie, I have not used that combo of drugs...but maybe this link Rich posted today might help you? It just so happens Dr. Slamon talks about Herceptin/Avastin in this article. I copied and pasted the one section for you if interested.

Dennis Slamon, a University of California, Los Angeles, oncologist who was part of the team that developed Herceptin back in the1980s, is enthusiastic about combining it with Genentech’s vascular endothelial growth factor (VEGF) inhibitor, Avastin (bevacizumab). Dr. Slamon points out that the two pathways are linked. When HER2 is amplified, “one of the pathways that consistently goes up is VEGF,”he says. Trials of the combination (Avastin plus Herceptin) have been encouraging. In phase 2 trials, “the two antibodies alone, with no chemo, are giving objective response rates in
54% of women with metastatic disease.” Used at earlier stages, Slamon believes the combination could be even more powerful and he is optimistic that this regimen will eventually be tested in a phase 3 trial without concomitant chemotherapy.

Just in case you want the entire link Rich posted for this I will include it.

http://www.nature.com/nbt/journal/v2...bt0210-117.pdf

Hopes it helps a little bit.

Chelee

02-26-2010, 09:32 PM	#2
Chelee Senior Member Join Date: Feb 2006 Location: Southern, CA Posts: 2,511	Re: Anybody used Herceptin with Avastin Julie, I have not used that combo of drugs...but maybe this link Rich posted today might help you? It just so happens Dr. Slamon talks about Herceptin/Avastin in this article. I copied and pasted the one section for you if interested. Dennis Slamon, a University of California, Los Angeles, oncologist who was part of the team that developed Herceptin back in the1980s, is enthusiastic about combining it with Genentech’s vascular endothelial growth factor (VEGF) inhibitor, Avastin (bevacizumab). Dr. Slamon points out that the two pathways are linked. When HER2 is amplified, “one of the pathways that consistently goes up is VEGF,”he says. Trials of the combination (Avastin plus Herceptin) have been encouraging. In phase 2 trials, “the two antibodies alone, with no chemo, are giving objective response rates in 54% of women with metastatic disease.” Used at earlier stages, Slamon believes the combination could be even more powerful and he is optimistic that this regimen will eventually be tested in a phase 3 trial without concomitant chemotherapy. Just in case you want the entire link Rich posted for this I will include it. http://www.nature.com/nbt/journal/v2...bt0210-117.pdf Hopes it helps a little bit. Chelee __________________ DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes. Rt. MRM on 1-3-06 -- No Rads due to compromised lungs. Chemo started 2-7-06 -- TCH - - Finished 6-12-06 Finished yr of wkly herceptin 3-19-07 3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07 9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV. 9-28-09 Loading dose of Herceptin & started Zometa 9-29-09 Power Port Placement 10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head. 11-19-09 RT. Femur surgery - Rod placed 12-7-09 Navelbine added to Herceptin/Zometa. 3-23-10 Ten days of rads to RT femur. Completed. 4-05-10 Quit Navelbine--Herceptin/Zometa alone. 5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy. Results to FISH was unsuccessful--this happens less then 2% of the time. 7-7-10 Recurrence to RT axilla again. Back to UCLA for options.