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chrisy · 02-25-2010, 05:26 PM

ANGELA
Hi,

I've never been on pertuzumab, or in the protocol that had pertuzumab. Only Trastuzumab (Herceptin) in it's plain vanilla or souped up TDM1 form.

I've posted replies on various threads about TDM1 studies that have pertuzumab arms.

I probably said I would love to try that combination, and I would, because of the potential blocking of multiple HER pathways. I've seen many discussions of this "total blockade" approach which some researchers believe is key to an actual cure.

There have actually been several studies of pertuzumab in combination with various things, but as of yet it is not FDA approved. There is currently a Phase III study ongoing with I think Pertuzumab vs. Herceptin. So it is not a completely unknown agent as far as side effects or even hints of efficacy. It's just not a "proven" therapy.

There have been smaller studies, here is a link to the press release on one, of Pertuzumab + Herceptin which shows promise.
http://www.roche.com/home/inv-update-2008-05-30a

If I got to design my own clinical trial, for people who do well on TDM1 - even to NED - I would go for a shuffle of TDM1, Herceptin and/or Tykerb, and Pertuzumab or something that would target Her3. But nobody would ever design a trial like that!

02-25-2010, 05:26 PM	#12
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Re: Bad MUGA scan might mean no herceptin? ANGELA Hi, I've never been on pertuzumab, or in the protocol that had pertuzumab. Only Trastuzumab (Herceptin) in it's plain vanilla or souped up TDM1 form. I've posted replies on various threads about TDM1 studies that have pertuzumab arms. I probably said I would love to try that combination, and I would, because of the potential blocking of multiple HER pathways. I've seen many discussions of this "total blockade" approach which some researchers believe is key to an actual cure. There have actually been several studies of pertuzumab in combination with various things, but as of yet it is not FDA approved. There is currently a Phase III study ongoing with I think Pertuzumab vs. Herceptin. So it is not a completely unknown agent as far as side effects or even hints of efficacy. It's just not a "proven" therapy. There have been smaller studies, here is a link to the press release on one, of Pertuzumab + Herceptin which shows promise. http://www.roche.com/home/inv-update-2008-05-30a If I got to design my own clinical trial, for people who do well on TDM1 - even to NED - I would go for a shuffle of TDM1, Herceptin and/or Tykerb, and Pertuzumab or something that would target Her3. But nobody would ever design a trial like that! __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure