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Rich66 · 01-09-2010, 08:55 PM

Go to this page and you can see Andrea and Steph N's treatment profiles in their posts. MamaCZ had complete remission on Navelbine/Herceptin. All had liver mets. Note that they are ER/PR-. Some significant thought out there that Chemo is not as helpful to ER+. But..there is some info and case studies regarding combining chemo and endocrine, i.e. "chemoendocrine" therapy. Rapamycin may be helpful in reversing resistance to some chemos. And the delivery of what you have already had may be worth investigating. Did you have Decadron (glucocorticoid) with your Taxotere? May have interfered. Some have revisited "failed" chemos in a lower-dose/metronomic fashion without breaks and had benefit. Cyclophosphamide is a favorite tool of metronomic guru, Dr. Kerbel. Capecitabine and Cyclophosphamide have been combined. Faslodex has been shown to synergize with chemo. There is thought that her2 therapies push the cancer to rely more heavily on estrogen and vice versa, suggesting blocking both pathways as best. There are strategies to sensitize or reverse resistance to ER therapies. Since Her2+ is more often ER-, it can be hard to good examples here. There are numerous liver directed thrapies. RFA, SirSpheresMy mom is in the exact same boat, mets-wise (though her2 borderline) as you and Xeloda gave her the best run so far.

01-09-2010, 08:55 PM	#4
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: What worked for you? Go to this page and you can see Andrea and Steph N's treatment profiles in their posts. MamaCZ had complete remission on Navelbine/Herceptin. All had liver mets. Note that they are ER/PR-. Some significant thought out there that Chemo is not as helpful to ER+. But..there is some info and case studies regarding combining chemo and endocrine, i.e. "chemoendocrine" therapy. Rapamycin may be helpful in reversing resistance to some chemos. And the delivery of what you have already had may be worth investigating. Did you have Decadron (glucocorticoid) with your Taxotere? May have interfered. Some have revisited "failed" chemos in a lower-dose/metronomic fashion without breaks and had benefit. Cyclophosphamide is a favorite tool of metronomic guru, Dr. Kerbel. Capecitabine and Cyclophosphamide have been combined. Faslodex has been shown to synergize with chemo. There is thought that her2 therapies push the cancer to rely more heavily on estrogen and vice versa, suggesting blocking both pathways as best. There are strategies to sensitize or reverse resistance to ER therapies. Since Her2+ is more often ER-, it can be hard to good examples here. There are numerous liver directed thrapies. RFA, SirSpheresMy mom is in the exact same boat, mets-wise (though her2 borderline) as you and Xeloda gave her the best run so far. __________________ Mom's treatment history (link)