HER2 Support Group Forums - View Single Post - many yrs ago Al from Canada asked for a natural PI3K inhibitor--

Lani · 01-08-2010, 10:34 AM

from the article:
Secreted by CD4+ and CD8+ -activated T cells [31] and by somatic cells [30], endogenous βGBP controls cell cycle entry and S/G2 traverse [30]. In its recombinant form βGBP

Thus they could try to increase the number of CD4+ and CD8+ activated T cells secreting beta GBP or provide more in its "recombinant form"--made by bacteria or in tobacco plants via gene therapy means.

This article is about a year old...it comes out of England where they are trying to find cheaper treatments as otherwise NICE won't approve them, so maybe someone/somewhere is starting/intending to start a clinical trial. Lots to figure out about how best to increase production of this natural substance, whether it needs to be raised continuously or intermittently, optimal level, how long to treat(perhaps a one time dose if appropriately targeted as it causes massive apoptosis), whether such massive apoptosis is prudent or whether lots of cell debris might overwhelm the kidneys...

Lots of work to be done, but hopeful!

01-08-2010, 10:34 AM	#12
Lani Senior Member Join Date: Mar 2006 Posts: 4,780	Re: many yrs ago Al from Canada asked for a natural PI3K inhibitor-- from the article: Secreted by CD4+ and CD8+ -activated T cells [31] and by somatic cells [30], endogenous βGBP controls cell cycle entry and S/G2 traverse [30]. In its recombinant form βGBP Thus they could try to increase the number of CD4+ and CD8+ activated T cells secreting beta GBP or provide more in its "recombinant form"--made by bacteria or in tobacco plants via gene therapy means. This article is about a year old...it comes out of England where they are trying to find cheaper treatments as otherwise NICE won't approve them, so maybe someone/somewhere is starting/intending to start a clinical trial. Lots to figure out about how best to increase production of this natural substance, whether it needs to be raised continuously or intermittently, optimal level, how long to treat(perhaps a one time dose if appropriately targeted as it causes massive apoptosis), whether such massive apoptosis is prudent or whether lots of cell debris might overwhelm the kidneys... Lots of work to be done, but hopeful!