HER2 Support Group Forums - View Single Post - latest on vaginal estrogen therapy, serum estradiol levels

AlaskaAngel · 01-02-2010, 07:08 PM

Keep an eye on this one:

"Among the old-school potential alternatives to vaginal estrogens for these patients are nonestrogenic vaginal lubricants such as K-Y Jelly and Replens. But the most exciting work in this area involves the use of intravaginal dehydroepiandrosterone (DHEA) capsules (prasterone), according to Dr. Loprinzi, professor of oncology at the Mayo Clinic, Rochester, Minn.

In a series of papers based on a recent phase III randomized, double-blind, placebo-controlled, 12-week clinical trial involving 216 postmenopausal women with vaginal atrophy, Dr. Fernard Labrie and workers at Laval University, Quebec, showed that intravaginal DHEA was highly and rapidly effective for the treatment of vaginal atrophy (Menopause 2009;16:907-22), significantly improved the patients' libido and sexual function (pp. 923-31 of the same issue of Menopause) and did so with no suggestion of an increase in serum sex steroid levels (pp. 897-906).

"I believe this is something that ideally should be replicated by another group. But it does look quite interesting," commented Dr. Loprinzi."

01-02-2010, 07:08 PM	#3
AlaskaAngel Senior Member Join Date: Sep 2005 Location: Alaska Posts: 2,018	Re: latest on vaginal estrogen therapy, serum estradiol levels Keep an eye on this one: "Among the old-school potential alternatives to vaginal estrogens for these patients are nonestrogenic vaginal lubricants such as K-Y Jelly and Replens. But the most exciting work in this area involves the use of intravaginal dehydroepiandrosterone (DHEA) capsules (prasterone), according to Dr. Loprinzi, professor of oncology at the Mayo Clinic, Rochester, Minn. In a series of papers based on a recent phase III randomized, double-blind, placebo-controlled, 12-week clinical trial involving 216 postmenopausal women with vaginal atrophy, Dr. Fernard Labrie and workers at Laval University, Quebec, showed that intravaginal DHEA was highly and rapidly effective for the treatment of vaginal atrophy (Menopause 2009;16:907-22), significantly improved the patients' libido and sexual function (pp. 923-31 of the same issue of Menopause) and did so with no suggestion of an increase in serum sex steroid levels (pp. 897-906). "I believe this is something that ideally should be replicated by another group. But it does look quite interesting," commented Dr. Loprinzi."