HER2 Support Group Forums - View Single Post

Becky · 12-31-2009, 01:53 PM

Tonya

There are results in trials for BRCA 1+ women who need to get propholactic oopherectomy and propholactic masectomies. The women who participated in this trial did so because they were reluctant to lose their breasts but wanted the ooph (as ovarian cancer is harder to survive anyway). Women with the BRCA 1 mutation get triple negative cancer probably 95% of the time.

This study showed that an ooph reduces the chance of bc in this population by 80% (and reduces the chance of bc in a general (non BRCA) population by 68%.

The BRCA 1+ women who then took Femara as well benefited even more.

So, I am not 100% sure about recurrence but I think it might help regardless of hormone status but one thing an ooph does do is reduce the chance of a new breast cancer.

12-31-2009, 01:53 PM	#5
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Oophrectomy Tonya There are results in trials for BRCA 1+ women who need to get propholactic oopherectomy and propholactic masectomies. The women who participated in this trial did so because they were reluctant to lose their breasts but wanted the ooph (as ovarian cancer is harder to survive anyway). Women with the BRCA 1 mutation get triple negative cancer probably 95% of the time. This study showed that an ooph reduces the chance of bc in this population by 80% (and reduces the chance of bc in a general (non BRCA) population by 68%. The BRCA 1+ women who then took Femara as well benefited even more. So, I am not 100% sure about recurrence but I think it might help regardless of hormone status but one thing an ooph does do is reduce the chance of a new breast cancer. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"