HER2 Support Group Forums - View Single Post

Becky · 12-21-2009, 09:06 PM

Alice

At SABCS 2007 there was a presentation aimed primarily at ER+PR- tumors where they took a "molecular" picture of the tumors and compared them to the molecular pictures of ER+PR+ and ER-PR- tumors.

Bottom line is some ER+PR- tumors look like ER+PR+ tumors and some look like ER-PR- tumors and some are truly unique and are thus ER+PR- (but just a small portion).

However, the presenter also said that some ER+PR+ tumors look like ER-PR- tumors (and vice versa) and this is probably what happened to you (perhaps).

They did not do this in conjunction with any other markers (such as Her2) but the presenter was indicating that this may be why some women don't respond to endocrine therapies - because their hormone positive cancer is actually very different than what is expected.

12-21-2009, 09:06 PM	#1
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: The weakly er+ group Alice At SABCS 2007 there was a presentation aimed primarily at ER+PR- tumors where they took a "molecular" picture of the tumors and compared them to the molecular pictures of ER+PR+ and ER-PR- tumors. Bottom line is some ER+PR- tumors look like ER+PR+ tumors and some look like ER-PR- tumors and some are truly unique and are thus ER+PR- (but just a small portion). However, the presenter also said that some ER+PR+ tumors look like ER-PR- tumors (and vice versa) and this is probably what happened to you (perhaps). They did not do this in conjunction with any other markers (such as Her2) but the presenter was indicating that this may be why some women don't respond to endocrine therapies - because their hormone positive cancer is actually very different than what is expected. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"