[Barbara2]

Thanks, Lani, for the interesting article.

It would be wonderful if a way could be found to reverse chemo brain. So many of us suffer from changes in our brains since chemo, but when we talk to our oncologists about our concerns, they can only tell us that some people complain of chemo brain, but doctors do not know if the disorder is fact or something the patient thinks exists. Patients, myself included, hate to complain too loudly because we are thankful for drugs that can fight cancer so we accept whatever changes we experience (physical changes, too) and try to move forward, although with lesser brain compacity it can be difficult and demoralizing.

I know the before and after (7 years March 2010) cognitive differences I have experienced and no one can convince me that what I am experiencing is from normal changes in brain function due to age, etc. But at the same time I will say "Praise the Lord" and give thanks for being able to duke it out with cancer (past, present, and future) no matter the side effects from the drugs that were used in the fight.

Unexpectedly, all four drugs caused a significant breakdown in brain cell proliferation in the animal model. Many of us have received some or all the the 4 drugs mentioned in this article. I am feeling some sort of relief or satisfaction, knowing that we are finally discovering that these drugs have very likely impacted people who have received them...often for months, weeks, or years after treatment. Even though I knew the changes I was experiencing were not imagined, it is good to see the cause/effect in writing!

One last note...I asked my onc if changes could be seen in an MRI, but he said the MRIs that we use for detecting metastasis, etc., are not the same as an MRI that would show brain function...if I understood that correctly...and that type of MRI is not available in most areas.