HER2 Support Group Forums - View Single Post - Are pre-meds needed...

Rich66 · 12-06-2009, 03:57 PM

I was wondering about that. I came across this last night:

http://doi.wiley.com/10.1002/cncr.10263
Abstract
BACKGROUND
Interstitial pneumonitis has not been reported as a toxicity of docetaxel. The authors report the presentation and natural history of four patients who developed a severe interstitial pneumonitis after receiving docetaxel.

METHODS
The hospital and outpatient records of patients treated with docetaxel were reviewed to identify whether any of these patients required an evaluation for respiratory problems.

RESULTS
Four patients developed an interstitial pneumonitis that could be explained only as a toxicity of docetaxel. None had metastatic disease to the lung, and all had normal liver function before receiving chemotherapy. The patients presented with acute dyspnea and fever within 1-2 weeks of receiving docetaxel. All developed progressive interstitial infiltrates and respiratory failure that required mechanical ventilation. An exhaustive workup for other causes of pneumonitis was negative. Broad-spectrum antibiotics and corticosteroids were ineffective. Two patients died of complications related to the pulmonary process. The two survivors required ventilatory support for more than 21 days. The clinical and pathologic findings of these patients are presented.

CONCLUSIONS
Interstitial pneumonitis is a rare and potentially fatal complication of docetaxel treatment. Prolonged ventilatory support is appropriate in patients with a favorable prognosis. Cancer 2002;94:847-53. © 2002 American Cancer Society.
DOI 10.1002/cncr.10263

Forgot to give neupogen? Is that what they said?

I assume you got a 3wk dose of Taxotere. What time of day did you get the Taxotere? Did they give the other components right after?

12-06-2009, 03:57 PM	#9
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Are pre-meds needed... I was wondering about that. I came across this last night: http://doi.wiley.com/10.1002/cncr.10263 Abstract BACKGROUND Interstitial pneumonitis has not been reported as a toxicity of docetaxel. The authors report the presentation and natural history of four patients who developed a severe interstitial pneumonitis after receiving docetaxel. METHODS The hospital and outpatient records of patients treated with docetaxel were reviewed to identify whether any of these patients required an evaluation for respiratory problems. RESULTS Four patients developed an interstitial pneumonitis that could be explained only as a toxicity of docetaxel. None had metastatic disease to the lung, and all had normal liver function before receiving chemotherapy. The patients presented with acute dyspnea and fever within 1-2 weeks of receiving docetaxel. All developed progressive interstitial infiltrates and respiratory failure that required mechanical ventilation. An exhaustive workup for other causes of pneumonitis was negative. Broad-spectrum antibiotics and corticosteroids were ineffective. Two patients died of complications related to the pulmonary process. The two survivors required ventilatory support for more than 21 days. The clinical and pathologic findings of these patients are presented. CONCLUSIONS Interstitial pneumonitis is a rare and potentially fatal complication of docetaxel treatment. Prolonged ventilatory support is appropriate in patients with a favorable prognosis. Cancer 2002;94:847-53. © 2002 American Cancer Society. DOI 10.1002/cncr.10263 Forgot to give neupogen? Is that what they said? I assume you got a 3wk dose of Taxotere. What time of day did you get the Taxotere? Did they give the other components right after? __________________ Mom's treatment history (link)