HER2 Support Group Forums - View Single Post - Ovarian Suppresion for Pre-Menopausal Women

Becky · 12-04-2009, 12:33 PM

http://theoncologist.alphamedpress.o...stract/9/5/507

http://www.guardian.co.uk/lifeandsty...-breast-cancer
http://jnci.oxfordjournals.org/cgi/c...ull/95/24/1811

I attached some articles for you to review. At SABCS 2007, this was a hot, hot topic and alot of posters and presentations saying it is better to suppress the ovaries and give Tamoxifen or an AI. Theoretically, if you are truly suppressed, then you could take an AI versus Tamoxifen as you truly would be deemed postmenopausal.

There are also the BRCA studies of having the ovaries propholactically removed (as BRCA mutations cause breast and ovarian cancers). They found that BRCA 1 women who removed the ovaries first and then just did surveillance on the breasts got far less bc's than BRCA 1 women who did not remove the ovaries.

There are studies (old time prior to "abalation drugs" that state that ovary removal reduces new bc rate by 68% but it studied rate of a new bc not recurrence rate of bc.

There is alot of info out there and it is a hotly researched topic. I think the overall concensus is that ablation does improve the odds overall (and that does make sense).

12-04-2009, 12:33 PM	#2
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Ovarian Suppresion for Pre-Menopausal Women - What is the Latest? http://theoncologist.alphamedpress.o...stract/9/5/507 http://www.guardian.co.uk/lifeandsty...-breast-cancer http://jnci.oxfordjournals.org/cgi/c...ull/95/24/1811 I attached some articles for you to review. At SABCS 2007, this was a hot, hot topic and alot of posters and presentations saying it is better to suppress the ovaries and give Tamoxifen or an AI. Theoretically, if you are truly suppressed, then you could take an AI versus Tamoxifen as you truly would be deemed postmenopausal. There are also the BRCA studies of having the ovaries propholactically removed (as BRCA mutations cause breast and ovarian cancers). They found that BRCA 1 women who removed the ovaries first and then just did surveillance on the breasts got far less bc's than BRCA 1 women who did not remove the ovaries. There are studies (old time prior to "abalation drugs" that state that ovary removal reduces new bc rate by 68% but it studied rate of a new bc not recurrence rate of bc. There is alot of info out there and it is a hotly researched topic. I think the overall concensus is that ablation does improve the odds overall (and that does make sense). __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"